How to Train Your Thoughts" chronicles the unique and compelling journey of Monde Kgoroge, a determined university student navigating the challenges of life in Cape Town. Working at a restaurant on Kloof Street, Monde finds solace in the company of four distinct voices in her head – Synapso, Thelial, Astro, and Dendro. These personified voices serve as Monde's inner advisors, helping her navigate the complexities of her daily experiences, including the exploitation she endures from her employer, Lee-Anne.
Despite facing mistreatment, Monde remains in denial, prompting her inner voices to embark on a mission to guide her towards acknowledging the reality of her situation. The quartet—Synapso, Thelial, Astro, and Dendro— work together with a friend from the depths of Monde's psyche to show her the importance of changing her attitude.
Through the ups and downs, Monde endeavors to convince the voices that she has a plan to alter her circumstances.